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Subjective cognitive decline and rates of incident Alzheimer's disease and non–Alzheimer's disease dementia
Author(s) -
Slot Rosalinde E.R.,
Sikkes Sietske A.M.,
Berkhof Johannes,
Brodaty Henry,
Buckley Rachel,
Cavedo Enrica,
Dardiotis Efthimios,
GuilloBenarous Francoise,
Hampel Harald,
Kochan Nicole A.,
Lista Simone,
Luck Tobias,
Maruff Paul,
Molinuevo José Luis,
Kornhuber Johannes,
Reisberg Barry,
RiedelHeller Steffi G.,
Risacher Shan L.,
Roehr Susanne,
Sachdev Perminder S.,
Scarmeas Nikolaos,
Scheltens Philip,
Shulman Melanie B.,
Saykin Andrew J.,
Verfaillie Sander C.J.,
Visser Pieter Jelle,
Vos Stephanie J.B.,
Wagner Michael,
Wolfsgruber Steffen,
Jessen Frank,
Flier Wiesje M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.10.003
Subject(s) - dementia , hazard ratio , memory clinic , medicine , alzheimer's disease , confidence interval , cognitive decline , incidence (geometry) , proportional hazards model , poisson regression , disease , gerontology , psychiatry , population , environmental health , optics , physics
In this multicenter study on subjective cognitive decline (SCD) in community‐based and memory clinic settings, we assessed the (1) incidence of Alzheimer's disease (AD) and non‐AD dementia and (2) determinants of progression to dementia. Methods Eleven cohorts provided 2978 participants with SCD and 1391 controls. We estimated dementia incidence and identified risk factors using Cox proportional hazards models. Results In SCD, incidence of dementia was 17.7 (95% Poisson confidence interval 15.2‐20.3)/1000 person‐years (AD: 11.5 [9.6‐13.7], non‐AD: 6.1 [4.7‐7.7]), compared with 14.2 (11.3‐17.6) in controls (AD: 10.1 [7.7‐13.0], non‐AD: 4.1 [2.6‐6.0]). The risk of dementia was strongly increased in SCD in a memory clinic setting but less so in a community‐based setting. In addition, higher age (hazard ratio 1.1 [95% confidence interval 1.1‐1.1]), lower Mini–Mental State Examination (0.7 [0.66‐0.8]), and apolipoprotein E ε4 (1.8 [1.3‐2.5]) increased the risk of dementia. Discussion SCD can precede both AD and non‐AD dementia. Despite their younger age, individuals with SCD in a memory clinic setting have a higher risk of dementia than those in community‐based cohorts.