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P4‐378: A MULTI‐DOMAIN VIRTUAL COGNITIVE HEALTH PROGRAM REDUCES SYMPTOMS OF DEPRESSION AND ANXIETY: SIX‐MONTH RESULTS FROM A SINGLE‐ARM LONGITUDINAL STUDY
Author(s) -
Bott Nicholas T.,
Kumar Shefali,
Moseson Heidi,
Uppal Jaspreet,
Tran Jennifer,
Glenn Jordan,
Juusola Jessie L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.202
Subject(s) - worry , anxiety , health coaching , psychological intervention , cognition , medicine , depression (economics) , mental health , longitudinal study , intervention (counseling) , cognitive decline , physical therapy , clinical psychology , gerontology , psychiatry , dementia , disease , pathology , economics , macroeconomics
modulate the disorder’s advancement. Methods: 122 older adults participated in the study (aging > 65). The sample included 52 healthy subjects and 71 SCD patients, whose PA was assessed into three different categories according to the short version of the International Physical Activity Questionnaire (IPAQ). We estimated functional connectivity in the alpha band using the Phase Locking Value (PLV) in 4 minutes eyes-closed resting records, and connectivity differences were evaluated using ANCOVA statistical analysis and a False Discovery Rate multiple comparisons correction. Results:The statistical analysis revealed higher connectivity values in healthy women when compared to healthy men, while that difference disappeared between men and women of the SCD group. On the other hand, no significant effect was detected regarding PA. Conclusions: This is to the best of our knowledge the first time that the effect of PA and sex in the first stages of AD has been evaluated. Our results suggest that sex has a significant effect on the functional networks of the brain and in the advancement of cognitive decline, since women’s connectivity values experience a higher decrease than men’s when going from a healthy stage to a SCD status. One of the possibilities that could explain the results obtained is that women have a higher cognitive reserve, implying that women are less likely to be addressed as dementia patients until major neurodegradation occurs. We are currently increasing the size of the sample and adding new factors that could influence the advancement as well in order to deepen our knowledge on the topic. Petersen, Ronald Carl, et al. "Prevalence of mild cognitive impairment is higher in men The Mayo Clinic Study of Aging.” Neurology 75.10 (2010): 889-897.