Premium
P4‐333: AUTOPSY FINDINGS OF CEREBRAL β‐AMYLOIDOSIS, TAUOPATHY, AND NEURODEGENERATION (A, T AND N) IN A COMMUNITY‐BASED SAMPLE: IMPLICATIONS FOR DEMENTIA MITIGATION STRATEGIES
Author(s) -
Burke Bridget Teevan,
Latimer Caitlin S.,
Keene Dirk C.,
Montine Thomas J.,
Sonnen Joshua,
McCormick Wayne,
Bowen James D.,
McCurry Susan M.,
Larson Eric B.,
Crane Paul K.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.156
Subject(s) - neuropathology , dementia , tauopathy , autopsy , medicine , neurodegeneration , cohort , alzheimer's disease , chronic traumatic encephalopathy , gerontology , disease , psychology , psychiatry , poison control , injury prevention , medical emergency , concussion
one visit with cognitive testing. There were 57 (20%) with LP, 22 (8%) with HpSp and 213 (73%) with tAD. For memory, language, and global scores, the HpSp group declined significantly faster, compared to tAD, while the LP group did not (Table 1). The HpSp group did not have relatively better memory performance prior to, at or after dementia diagnosis.Conclusions:The relative frequency and rate of cognitive decline of AD neuropathological subtypes in a population-based sample were similar to previous reports from a convenience sample. However, AD neuropathological subtypes may be incongruous with clinical AD subtypes defined by relative cognitive impairment.