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P4‐326: REDUCED LOCUS COERULEUS INTEGRITY IS ASSOCIATED WITH ELEVATED WHITE MATTER LESION PATHOLOGY IN OLDER ADULTS WITHOUT DEMENTIA
Author(s) -
Weigand Alexandra J.,
Delano-Wood Lisa,
Bangen Katherine J.,
Edmonds Emily C.,
Eppig Joel S.,
Weharne Madeleine L.,
Igwe Kay C.,
Granholm Eric L.,
Frank Lawrence R.,
Brickman Adam M.,
Bondi Mark W.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.149
Subject(s) - locus coeruleus , hyperintensity , dementia , white matter , neuromelanin , pathology , psychology , cardiology , medicine , vascular dementia , context (archaeology) , neuroscience , magnetic resonance imaging , disease , biology , central nervous system , radiology , paleontology , parkinson's disease , substantia nigra
ReHo Putamen L -0.14 0.00 0.03 -0.17 -0.16 -0.09 Inferior temporal gyrus L 0.11 0.07 -0.19 -0.18 -0.27 -0.14 FC (Seed region: Putamen_L) Middle frontal gyrus L -0.15 -0.14 -0.08 -0.20 -0.21 -0.21 Middle frontal gyrus R -0.11 -0.21 -0.14 -0.34 -0.24 -0.31 Midcingulate area R -0.18 -0.22 -0.19 -0.28 -0.21 -0.29 FC (Seed region: Temporal_Inf_L) Gyrus rectus L -0.01 -0.00 -0.07 -0.16 0.05 -0.05 Middle frontal gyrus L 0.30 0.36* 0.47* 0.24 0.22 0.41 Middle frontal gyrus R 0.17 0.16 0.40* 0.17 0.03 0.23 Supplementary motor area R 0.12 0.06 0.40* 0.08 -0.11 0.11 ReHo of ROIs M iddle frontal gyrus L 0.03 0.14 0.05 -0.08 -0.04 0.04 Middle frontal gyrus R 0.03 0.31 0.04 -0.01 0.13 0.20 Midcingulate area R -0.19 0.14 0.01 -0.18 -0.12 -0.02 ReHo of ROIs Gyrus rectus L -0.05 -0.02 0.04 0.05 -0.16 -0.04 Middle frontal gyrus L 0.09 0.24 0.11 0.01 0.00 0.15 Middle frontal gyrus R -0.10 0.26 0.00 -0.01 0.04 0.14 Supplementary motor area R -0.12 0.10 -0.20 -0.21 -0.14 -0.10