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P4‐320: DURA MATTERS: FAILURE TO ACCOUNT FOR THE DURA MATER CONFOUNDS MEASURES OF ATROPHY IN CORTICAL REGIONS LINKED TO THE EARLIEST NEUROFIBRILLARY TANGLE PATHOLOGY
Author(s) -
Xie Long,
Wisse Laura,
Das Sandhitsu R.,
Ittyerah Ranjit,
Wolk David A.,
Yushkevich Paul A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.143
Subject(s) - entorhinal cortex , temporal lobe , atrophy , perirhinal cortex , anatomy , cortex (anatomy) , neuroscience , dura mater , pathology , psychology , hippocampus , medicine , epilepsy
RI (A) but can be easily separated in T2-weighted MRI (B). Conventional ethod commonly mislabels the dura as gray matter (red arrows in C), hich potentially confounds findings of research studies. ASHS-T1 is ble to separate dura from gray matter (D) and generate reliable segmentaon of the medial temporal lobe substructures. Abbreviations: ERC1⁄4 entoinal cortex; BA35/36 1⁄4 Brodmann areas 35/36. Poster Presentations: Wednesday, July 25, 2018 S1581