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P4‐304: RELATIONSHIP BETWEEN AORTIC AUGMENTATION INDEX BY RADIAL ARTERY TONOMETRY AND CEREBRAL PULSATILITY INDEX IN INDIVIDUALS AT RISK FOR ALZHEIMER'S DISEASE
Author(s) -
Russek Natanya S.,
Gepner Adam D.,
Korcarz Claudia E.,
Berman Sara Elizabeth,
Lazar Karen K.,
Ma Yue,
Hoffman Carson A.,
Rivera Leonardo A.,
Austin Benjamin,
Chappell Richard J.,
Clark Lindsay R.,
Oh Jennifer M.,
Illingworth Chuck,
Jacobson Laura,
Blazel Hanna,
Gleason Carey E.,
Bendlin Barbara B.,
Asthana Sanjay,
Turski Patrick,
Johnson Sterling C.,
Stein James H.,
Wieben Oliver,
Carlsson Cynthia M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.127
Subject(s) - cardiology , medicine , population , arterial stiffness , middle cerebral artery , blood pressure , ischemia , environmental health
Background:Autopsy studies have consistently reported that neurofibrillary tau tangles, rather than the amyloid-b neuritic plaques, are associated AD neurodegeneration pattern. Furthermore, higher rates of neurodegeneration have prognostic value in predicting conversion frommild cognitive impairment to AD and increased risk of developing AD dementia in cognitively normal individuals. Methods:We obtained longitudinal-sectional multimodality neuroimaging data(structural-MRI for cortical thickness and flortaucipirPET for tau pathology) at two time-points (1.2960.33 years apart) from 25 cognitively healthy elderly individuals(9 Ab+) and 20 older individuals withMCI(8 Ab+) from the ADNI study. Time difference between MRI and PET imaging sessions was 1.2161.37 months at baseline and 0.35 6 0.53 months at the follow-up visit. Within each group, separate sparse whole brain multimodality canonical correlation analyses were performed to assess 1) the covarying brain patterns of current levels of tau pathology and rates of cortical thinning from a prognostic perspective, and 2) the covarying brain patterns of rates of tau pathology accumulation and rates of cortical thinning from a pathophysiological progression perspective. Results: Higher levels of current tau pathology in medial temporal and inferior temporal regions were associated with greater rates of cortical thinning in prefrontal cortex (predominantly regions highly associated with attention) with relatively lower cortical thinning rates in medial temporal regions in cognitively normals, and 2) higher rates of temporo-occipital and medial orbitofrontal cortical thinning in MCI(Figure 1).In contrast, greater rates of cortical thinning in prefrontal cortex as well as central insula were associated with a pattern of higher levels of rates of tau accumulation in superior frontal regions in cognitively normals (Figure 2). In MCIs, increased focal rates of cortical thinning in dorsolateral frontal, inferior parietal lobule, and inferior temporal cortex were associated with higher levels of rates of tau accumulation in inferior parietal lobule(Figure 2). Conclusions: Our work found that rates of neurodegeneration were associated with both concurrent and longitudinal tau accumulation in distant brain regions. These results are consistent with previously proposed model of pathophysiological spread of AD in brain networks. Validation of our findings in larger sample size cohorts might elucidate the temporal ordering of tau-PET relative to structural-MRI as imaging markers of disease progression and prognosis.