Premium
P4‐293: RELATIONSHIP BETWEEN ALZHEIMER'S DISEASE BIOMARKERS AND CHANGE IN MYELIN AMONG COGNITIVELY UNIMPAIRED ADULTS
Author(s) -
Kelley Jessica K.,
Merluzzi Andrew P.,
Dean Douglas C.,
Vogt Nicholas M.,
Asthana Sanjay,
Johnson Sterling C.,
Zetterberg Henrik,
Blennow Kaj,
Alexander Andrew L.,
Bendlin Barbara B.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.115
Subject(s) - myelin , white matter , magnetic resonance imaging , pathology , medicine , biomarker , alzheimer's disease neuroimaging initiative , amyloid (mycology) , disease , cerebrospinal fluid , psychology , neuroscience , alzheimer's disease , biology , central nervous system , radiology , biochemistry
Figure 1. Relationship between NGRN and myelin change over approximately two years, with 95% confidence intervals (R1⁄40.216). Linear regression revealed a positive correlation in three regions, two corresponding to white matter underlying the superior frontal gyrus, and one corresponding to the corpus callosum. Shown is the region corresponding to the corpus callosum. Rok Po zar, Bruno Giordani, Voyko Kavcic, University of Primorska, Faculty of Mathematics, Natural Sciences and Information Technologies, Koper, Slovenia; University of Primorska, Andrej Maru si c Institute, Koper, Slovenia; Michigan Alzheimer’s Disease Center, Ann Arbor, MI, USA; Wayne State University, Detroit, MI, USA; International Institute of Applied Gerontology, Ljubljana, Slovenia. Contact e-mail: giordani@med.umich.edu