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P4‐275: THE EMERGING CEREBROSPINAL FLUID BIOMARKER SNAP‐25 IS ELEVATED IN APOEε4 CARRIERS IN COGNITIVELY NORMAL INDIVIDUALS
Author(s) -
Sutphen Courtney L.,
Herries Elizabeth M.,
Gordon Brian A.,
Benzinger Tammie L.S.,
Xiong Chengjie,
Cruchaga Carlos,
Ladenson Jack H.,
Fagan Anne M.,
Schindler Suzanne E.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.097
Subject(s) - cerebrospinal fluid , apolipoprotein e , neurogranin , snap , biomarker , medicine , cohort , amyloid (mycology) , endocrinology , psychology , standardized uptake value , oncology , gastroenterology , positron emission tomography , pathology , nuclear medicine , chemistry , disease , biochemistry , kinase , computer graphics (images) , protein kinase c , computer science
With respect to CSFAD biomarkers, therewas a significant positive relationship between CSF TMAO and p-tau (b1⁄40.09, p1⁄40.006) and p-tau/Ab42 (b1⁄40.11, p1⁄40.013; Figure 1B). There was no significant relationship between CSF TMAO and Ab42/Ab40 (b1⁄4-0.003, p1⁄40.13). Conclusions:CSF TMAO, a gut microbial-derived metabolite, is higher in individuals with MCI and dementia due to AD, and higher CSF TMAO is associated with elevated AD pathology as measured by CSF biomarkers. While these findings suggest a potential role for TMAO in AD, additional studies are needed to further characterize this relationship and potential mechanisms.