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P4‐253: MULTI‐OMICS PROFILING IDENTIFIES APOE‐ALLELE‐ASSOCIATED LIPID AND GENE EXPRESSION PATTERNS IN ALZHEIMER'S DISEASE
Author(s) -
Lefterov Iliya,
Fitz Nicholas F.,
Wolfe Cody M.,
Nam Kyong Nyon,
Letronne Florent,
Kofler Julia,
Han Xianlin,
Schug Jonathan,
Koldamova Radosveta
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.07.075
Subject(s) - apolipoprotein e , biology , transcriptome , allele , lipidomics , trem2 , gene expression profiling , genetics , gene , microglia , gene expression , disease , inflammation , bioinformatics , immunology , medicine
Age (y) 35.393 9.21 64.5 11.64 31.941 11.46 73.667 12.89 83.714 6.1 ANOVA p<0.001 Pm Delay (h) 48.336 18.3 57.661 27.13 34.118 19.95 56.172 25.32 42.875 29.49 Kwallis p1⁄40.045 Cause of death Suicide 28 30 0 0 0 Accident 0 0 8 9 0 Natural causes 0 0 9 33 28 DSM Axis 1 Diagnosis Nil 0 0 17 42 0 Major depressive disorder 22 23 0 0 0 Depressive Disorder NOS 6 7 0 0 0 Dementia/possible dementia 0 0 0 0 28 DSM Axis 1 dependence 0 0 0 Nil 21 27 17 42 28 Substance 6 3 0 0 0 Alcohol 1 0 0 0 0 Psychotropic medications in last 3 months 15 9 17 20 0 Nil 0 6 0 2 0 Antidepressant 0 0 0 1 0 Antipsychotic 1 4 0 2 1 Benzodiazepine 1 1 0 0 0 Mood stabiliser 11 10 0 2 0 Antidepressant + another class Unknown 15 27 Braak stage 1.714 1.14 3.773 0.43 OFC Ab40 (ng/ml) 14.876 19.64 22.168 32.64 8.549 19.63 80.295 250.01 230.563 202.98 Kwallis p<0.001 OFC Ab42 (ng/ml) 42.777 63.46 265.668 692.21 21.251 25.32 520.9 892.79 3481.984 2382.29 Kwallis p<0.001 OFC Hb (g/dl) 0.293 0.3 0.299 0.3 0.375 0.44 0.314 0.24 0.216 0.16 Kwallis X1⁄43.23, p1⁄40.52 OFC MAG (ng/ml) 114.865 42.27 126.282 47.02 115.905 46.64 120.424 25.93 126.443 31.3 MAG:PLP ratio 16.21 3.61 13.80 3.40 13.32 2.95 15.59 3.74 15.49 4.23 ANOVA p1⁄40.036 OFC PLP (ng/ml) 7.252 3.02 9.582 4.92 10.468 10.54 8.235 2.78 8.491 2.29 OFC VEGF (ng/ml) 0.66 0.38 0.719 0.49 0.412 0.22 1.002 0.66 0.948 0.72 ANOVA p1⁄40.114 Poster Presentations: Wednesday, July 25, 2018 P1543