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P2‐309: PREVALENCE OF OBSTRUCTIVE SLEEP APNEA IN ALZHEIMER'S DISEASE PATIENTS
Author(s) -
Piñol Gerard,
Gibert Aurora,
Jorge Carmen,
Carnes Anna,
Huerto Raquel,
Fatzekas Faride,
Barbe Ferran
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.999
Subject(s) - medicine , epworth sleepiness scale , obstructive sleep apnea , polysomnography , sleep apnea , prospective cohort study , physical therapy , neuropsychology , cognition , pediatrics , apnea , psychiatry
distinguishing features of this disease can improve accuracy of early diagnosis. We characterized color vision impairment (CVI) in DLB patients to better understand its diagnostic utility. Methods: We retrospectively reviewed charts of patients with DLB patients and patients with mild cognitive impairment suspected to be in the prodromal phase of DLB (pro-DLB). All patients underwent an online 15-hue color vision arrangement test. Furthermore we reviewed DaT-SCAN SPECTand volumetricMRIs (available in 62% and 44% of patients, respectively). Results: Sixty-six subjects (17 pro-DLB and 49 DLB) were included in this study with a median age of 75 years and 45% were female. In the entire cohort, the symptom prevalence was: visual hallucinations (82%), abnormal DaT-SCAN (76%), tremor (74%), anosmia (71%), possible REM-behavior disorder (61%), bradykinesia (53%), and rigidity (45%). After the excluding patients who reported having color vision impairment from a young age (n1⁄42), the rate of CVI in the cohort was 64% (n1⁄441). No significant differences in gender, age, or DaT-SCAN results existed between patients with CVI vs. without CVI. Finally, we performed a multivariate stepwise logistic regression to predict which factors were significantly associated with CVI in our cohort. Overall three factors (lower MOCA total score (p1⁄40.007), postural tremor (p1⁄40.03), and anosmia (p1⁄40.03)) were independently associated with CVI. Conclusions: Color vision impairment in DLB patients occurred with similar prevalence to the core features of DLB (w70%) and was present in about half of patients with the prodromal form. Further studies are needed to determine relationships between CVI and volumetric changes on MRI and prospectively validate its diagnostic utility.