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P2‐290: ELECTROENCEPHALOGRAM FINDINGS IN PATIENTS WITH POSTERIOR CORTICAL ATROPHY
Author(s) -
Goldstein Eric D.,
Stephens Alana,
Graff-Radford Neill R.,
Carrasquillo Minerva M.,
Boeve Bradley F.,
Tatum William O.,
Ertekin-Taner Nilufer,
Feyissa Anteneh M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.979
Subject(s) - electroencephalography , temporal lobe , atrophy , epilepsy , neuroimaging , posterior cortical atrophy , medicine , neuropsychology , psychology , audiology , cardiology , disease , cognition , psychiatry , dementia
method. dT2Awas strongly correlated with Clinical Dementia Rating Scale “sum of boxes” (CDR-SB) in both studies, and dT2A exhibited a high Area Under the Receiver Operating Characteristic Curve (AUC) for the discrimination of Alzheimer’s Disease (AD) v. Normal Controls (NC) in both studies. As a demonstration of d’s indifference to its indicators, we modeled alternative homologs with fewer cognitive indicators. Homologs lacking any combination of Logical Memory II, Boston Naming and /or Animal Naming performed similarly to the full dT2A homolog. Conclusions: This is the twelfth d homolog validated to date. Regardless of its indicators, d correlates strongly with CDR-SB and accurately diagnoses dementia, across diagnoses and multiple cohorts. This implicates g as dementia’s essential cognitive impairment.