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P2‐289: CLINICAL PROFILE OF BEHAVIORAL AND PSYCHOLOGICAL SYMPTOMS IN ELDERLY WITH DEMENTIA
Author(s) -
Sivakumar Palanimuthu T.,
Nagalakshmi R.M.,
Sinha Preeti,
Thirumoorthy A.,
Varghese Mathew
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.978
Subject(s) - dementia , irritability , medicine , psychiatry , aggression , clinical psychology , disease , anxiety
method. dT2Awas strongly correlated with Clinical Dementia Rating Scale “sum of boxes” (CDR-SB) in both studies, and dT2A exhibited a high Area Under the Receiver Operating Characteristic Curve (AUC) for the discrimination of Alzheimer’s Disease (AD) v. Normal Controls (NC) in both studies. As a demonstration of d’s indifference to its indicators, we modeled alternative homologs with fewer cognitive indicators. Homologs lacking any combination of Logical Memory II, Boston Naming and /or Animal Naming performed similarly to the full dT2A homolog. Conclusions: This is the twelfth d homolog validated to date. Regardless of its indicators, d correlates strongly with CDR-SB and accurately diagnoses dementia, across diagnoses and multiple cohorts. This implicates g as dementia’s essential cognitive impairment.