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P2‐273: CEREBROSPINAL FLUID NEUROFILAMENT LIGHT PROTEIN AND RISK OF MILD COGNITIVE IMPAIRMENT IN THE MAYO CLINIC STUDY OF AGING
Author(s) -
Kern Silke,
Syrjanen Jeremy,
Blennow Kaj,
Zetterberg Henrik,
Skoog Ingmar,
Waern Margda,
Hagen Clinton E.,
Corien van Harten Argonde,
Knopman David S.,
Jack Clifford R.,
Petersen Ronald C.,
Mielke Michelle M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.962
Subject(s) - cerebrospinal fluid , quartile , medicine , cognitive impairment , risk factor , population , confidence interval , disease , environmental health
between spindle frequency activity (SFA), objectively-measured sleep disturbance, and the volume of key subcortical nuclei integral to sleep and memory. Methods: Sixty participants with multidomain MCI and 40 cognitively intact control subjects underwent comprehensive psychiatric, medical, and neuropsychological assessment, followed by overnight polysomnography. Power spectral analysis (PSA) was conducted on the sleep EEG to generate three markers of SFA: overall sigma power (12-15 Hz); slow (1113 Hz) and fast (13-15 Hz). A subsample (n 1⁄4 19 controls, n 1⁄4 37 MCI) also underwent neuroimaging from which volumes of the caudate nucleus, thalamus and hippocampus were quantified. Results: The MCI group had significantly reduced SFA in NREM sleep predominantly in the slow spindle frequency range. Reduced SFA in the MCI group was also associated with greater nocturnal awakenings. For the neuroimaging subsample, there was a statistically significant yet differential relationship between brain integrity and sigma power; for the control sample, increased SFAwas associated with having smaller right thalamus and hippocampal volume. By contrast, for those with MCI, the correlation between SFA and regional volumes were not significant. Conclusions:Whilst sleeping, individuals with MCI exhibit pronounced alterations in the sigma frequency range, relative to controls, suggestive of altered sleep spindles. Differential relationships between sigma power and both thalamus and hippocampal volumes suggests that these structures may be linked pathophysiologically to sleep disturbance in ageing and neurodegeneration.