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P2‐272: REDUCED SPINDLE FREQUENCY ACTIVITY DURING SLEEP IN MILD COGNITIVE IMPAIRMENT: DISTINCT RELATIONSHIPS WITH THALAMUS AND HIPPOCAMPUS
Author(s) -
Naismith Sharon L.,
Pye Jonathon,
Grunstein Ron,
Kim Jong-Won,
Cross Nathan,
Mowszowski Loren,
Lewis Simon JG.,
Duffy Shantel L.,
D'Rozario Angela
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.961
Subject(s) - thalamus , sleep spindle , non rapid eye movement sleep , audiology , psychology , neuroscience , electroencephalography , polysomnography , hippocampus , sleep (system call) , sleep stages , neuropsychology , cognition , medicine , computer science , operating system
Figure 1. CSF values by biomarker group. Results are boxplots (displaying first quartile, median and third quartile) and scatterplots for all CSF measures by each biomarker subgroup: (A) Neurofilament-light, (B) Neurogranin, (C) YKL-40, (D) amyloid-b1-38, (E) amyloid-b1-40, (F) amyloid-b142, (G) amyloid-b142/1-40, (H) total tau, (I) phosphorylated tau. The MCI A-T+ group is presented in blue and the CN A-T-, MCI A-T-, MCI A+T-, MCI A+T+, and AD dementia A+T+ groups are presented in grey. CSF biomarker values were logtransformed. *indicates statistically significant differences compared to the MCI A-T+ group after Bonferroni correction for multiple comparisons. A1⁄4amyloid-pi-42, T1⁄4total or phosphorylated tau, CN1⁄4cognitively normal, MCI1⁄4mild cognitive impairment.