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P2‐271: ADDIA, A MULTICENTER CLINICAL STUDY OF PROOF‐OF‐PERFORMANCE TO VALIDATE BLOOD‐BASED BIOMARKERS FOR THE DIAGNOSIS OF ALZHEIMER'S DISEASE (AD): THE STUDY PROTOCOL
Author(s) -
Dubois Bruno,
Bier Jean-Christophe,
Blanc Frederic,
David Renaud,
Démonet Jean-François,
Firat Hüseyin,
Frisoni Giovanni B.,
Gabelle Audrey,
Gurvit Hakan I.,
Ivanoiu Adrian,
Magnin Eloi,
Marizzoni Moira,
Moussaoui Saliha,
Pasquier Florence,
Sellal François
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.960
Subject(s) - cluster analysis , computer science , data mining , fuzzy clustering , dimension (graph theory) , raw data , cure data clustering algorithm , principal component analysis , reduction (mathematics) , dimensionality reduction , artificial intelligence , mathematics , geometry , pure mathematics , programming language
Figure 1. CSF values by biomarker group. Results are boxplots (displaying first quartile, median and third quartile) and scatterplots for all CSF measures by each biomarker subgroup: (A) Neurofilament-light, (B) Neurogranin, (C) YKL-40, (D) amyloid-b1-38, (E) amyloid-b1-40, (F) amyloid-b142, (G) amyloid-b142/1-40, (H) total tau, (I) phosphorylated tau. The MCI A-T+ group is presented in blue and the CN A-T-, MCI A-T-, MCI A+T-, MCI A+T+, and AD dementia A+T+ groups are presented in grey. CSF biomarker values were logtransformed. *indicates statistically significant differences compared to the MCI A-T+ group after Bonferroni correction for multiple comparisons. A1⁄4amyloid-pi-42, T1⁄4total or phosphorylated tau, CN1⁄4cognitively normal, MCI1⁄4mild cognitive impairment.

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