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P2‐267: NOVEL DIGITAL VOICE BIOMARKERS OF DEMENTIA FROM THE FRAMINGHAM STUDY
Author(s) -
Stück David,
Signorini Alessio,
Al Hanai Tuka,
Sandoval Maggie,
Lemke Christine,
Glass Jim,
Hardy Spencer,
Lavallee Maria,
Wasserman Brynna,
Alvin Ang Ting Fang,
Nowak Christina,
Au Rhoda
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.956
Subject(s) - random forest , computer science , dementia , artificial intelligence , classifier (uml) , receiver operating characteristic , metric (unit) , framingham heart study , test set , speech recognition , framingham risk score , machine learning , disease , medicine , pathology , operations management , economics
Background:When traveling on a route from start to destination, the traveler may check his/her current location at waypoints, or called sense of location (SoL). One way to test SoL is to ask an individual to send a signal when he/she is arriving at a waypoint or destination of a journey. This study aimed at comparing the SOL (am I here?) among mild Alzheimer’s disease (AD), mild cognitive impairment (MCI) and cognitively healthy control (CHC) groups.Methods: We invited 20 CHC (MMSE 28.2 [1.8]), 23 individuals with MCI (MMSE1⁄424.4 [3.4]) and 16 with mild AD (MMSE1⁄421.6 [2.9], mean [S.D.]) to join the study. The participants were instructed to press a key on a plate PC when they thought they had reached a target point as told before the experiments. The experiment was taken on a campus of NCKU, with 660 meters in length on which a total of 5 points were carefully chosen. Two raters were walking behind the participant after the instruction was given and fully comprehension was confirmed. Pai-Jan (PJ) device automatically recorded the response and traced the route a participants had walked on. We measured the linear deviation in meters and angular deviation in degrees from each target for group comparison. Results: Regarding the linear deviation, the averaged errors in meters in the CHC, MCI and AD were 18.6 [10.0], 47.5 [38.6] and 61.1 [35.9] respectively (p<0.001). In the same way, the averaged angular deviations in degrees among the groups were 10.5 [13.2] for CHC, 20.3 [20.3] for MCI, and 26.8 [16.6] for AD respectively (p<0.05). No difference, however, was detected among the three groups in vector to the start in degrees. As for the traces recorded by PJ Device, the consistency of the traces made by CHC were much better those that of MCI or AD. Conclusions: The performance of SoL was impaired in both MCI and AD as compared with CHC. Its clinical and neuropsychological significance need further investigation. In the near future, the PJ Device will be designed to direct people who lost their SoL.