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P2‐262: A CEREBROSPINAL FLUID PANEL OF SYNAPTIC PROTEINS ACROSS THE ENTIRE ALZHEIMER'S DISEASE CONTINUUM
Author(s) -
Belbin Olivia,
Núñez-Llaves Raúl,
Alcolea Daniel,
Balateu Daniel,
Colom-Cadena Martí,
Gomez-Giro Gemma,
Muñoz-Llahuna Laia,
Querol-Vilaseca Marta,
Pegueroles Jordi,
Rami Lorena,
Lladó Albert,
Molinuevo Jose Luis,
Tainta Mikel,
Clarimon Jordi,
Spires-Jones Tara,
Blesa Rafael,
Fortea Juan,
Martinez-Lage Pablo,
Sanchez-Valle Raquel,
Bayés Àlex,
Lleó Alberto
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.951
Subject(s) - neurodegeneration , synapse , neuroscience , cerebrospinal fluid , proteomics , biology , biomarker , alzheimer's disease , pathology , chemistry , medicine , disease , biochemistry , gene
and highest values. Remarkably, CECs CSF for N9 microglia and for J774 macrophages were nearly identical (R1⁄40.94; P<0.0001). CECs CSF for SH-SY5Y, A172 and N9 cells were correlated with one another less (R1⁄40.66-0.78; P<0.0001). CECs CSF for SH-SY5Y, A172 and N9 were strongly correlated with CSF apo A-I (R1⁄40.42-0.7) and apo J (R1⁄40.73-0.85) and weakly correlated with apo E (R1⁄40.28-0.39). After adjustment for apo J, the association between CECs CSF and apo A-I was no longer significant. Conclusions: CECs CSF for SH-SY5Y, A172 and N9 cells exhibit notable variability from individual to individual and from one and another and are determined mainly by CSF apo J levels.