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P2‐241: FROM BLOOD‐BASED REDOX PROFILE TO THE IDENTIFICATION OF A LEAD BIOMARKER FOR THE TIMELY DIAGNOSIS OF ALZHEIMER'S DISEASE
Author(s) -
Abate Giulia,
Vezzoli Marika,
Martinez Carmen,
Cueto Fernando,
Novelli Antonello,
Guaita Antonio,
Zetterberg Henrik,
Memo Maurizio,
Uberti Daniela
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.928
Subject(s) - biomarker , population , random forest , antioxidant , redox , glutathione peroxidase , oxidative stress , medicine , pathology , oncology , bioinformatics , chemistry , biochemistry , superoxide dismutase , artificial intelligence , biology , computer science , environmental health , organic chemistry
Nailfold capillary feature Category Multivariable* odds ratio (95% confidence interval) Unadjusted P value FDRAdjusted P value Mean tortuosity scorey 0 to <1 1.0 (ref) 1 to <2 3.4 (1.0, 12.2) .060 .083 2 14.1 (3.1, 63.9) .0006 .0036 Number of hemorrhages per 100 capillaries 0 to <1 1.0 (ref) 1 to <2 8.4 (1.9, 36.6) .0045 .014 2 4.4 (1.3, 14.9) .019 .037 Number of avascular zones 100 microns per 100 capillaries 0 to <1 1.0 (ref) 1 to <2 2.3 (0.6, 8.7) .23 .23 22 2.9 (0.9, 9.0) .069 .083