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P2‐227: STUDY OF CORRELATION BETWEEN BODY COMPOSITION AND THE ABSENCE OF OBJECTIVE COGNITIVE OR FUNCTIONAL IMPAIRMENT, MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DEMENTIA
Author(s) -
Bicalho Maria Aparecida,
Soares Thayana,
Simas Kaique,
Souza Anna Luiza,
Cintra Marco Túlio,
Lage Ariane Flávia,
Ávila Rafaela,
Malheiro Olívio Brito,
Souza Socorro,
Freitas Isabela Macedo,
Valadão Daniela
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.914
Subject(s) - sarcopenia , dementia , medicine , overweight , lean body mass , population , body mass index , cognitive impairment , neuropsychology , gerontology , risk factor , physical therapy , cognition , body weight , psychiatry , environmental health , disease
dementia subtypes and controls. Methods: 87 participants were recruited across three groups; 33 Alzheimer’s Disease (AD;(mean6sd) Age: 7867; MMSE: 2364), 27 Lewy Body Dementia (LBD; Age: 7867; MMSE: 2463) and 27 controls (Age:7469; MMSE: 2961). Dementia subtypes ranged from mild cognitive impairment to moderate dementia. A tri-axial accelometer (Axivity AX3) recorded data pertaining to gait and walking activity over 7 days. One way ANOVAs and non-parametric equivalents assessed group differences. Results: Preliminary results report significant gait impairments in both disease groups compared to controls for pace (step velocity, step length; (p .05)) and asymmetry (step, stance and swing time asymmetry (p .05); Figure 1). LBD alone were more variable in gait (step, stance, swing time and step velocity variability; (p .05)) compared to both AD and controls. People with LBD were also more variable than AD for step velocity (p 1⁄4 .021) and step length variability (p1⁄4 .041). LBD spent less time walking compared to controls and AD (p .05; Figure 2). AD took fewer average steps per day compared to controls (p1⁄4.019). LBD and AD were less variable in their walking bouts, and LBD performed a greater proportion of shorter walking bouts (higher alpha) compared to controls. Conclusions:Body-worn sensors provide an individualised representation of gait with information about discrete characteristics of gait impairment and changes in walking activity across all stages of cognitive impairment. This is important for both diagnostic and interventional purposes. Future research should aim to establish effects of environmental context on gait in free-living conditions to refine clinical interpretation.