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P2‐220: CROSS‐TALK BETWEEN WNT SIGNALLING AND AMYLOID PRECURSOR PROTEIN IN NEURONS
Author(s) -
Ehyai Saviz,
Abramsson Alexandra,
Zetterberg Henrik
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.908
Subject(s) - wnt signaling pathway , microbiology and biotechnology , amyloid precursor protein , immunoprecipitation , catenin , effector , chemistry , colocalization , biology , signal transduction , biochemistry , gene , alzheimer's disease , medicine , disease , pathology
The LMW population comprised monomeric and low-order oligomeric Ab1–42. The HMW population contained protofibrils (PF). Results:We found Ab1–42 fibrils was mainly formed not from PF but from LMW of Ab1–42. In addition, we also observed dissociation of single PF to LMW in PF incubation. Conclusions:These results supports that PF is off-pathway aggregate in Ab fibril formation. We discuss new possible mechanism in the assembly model from soluble state such as monomeric Ab to final state such as mature fibrils.