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P2‐199: 5LO GENETIC DELETION ATTENUATES NEUROINFLAMMATION IN A P301S MOUSE MODEL OF TAUOAPTHY
Author(s) -
Vagnozzi Ala.,
Pratico Domenico
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.886
Subject(s) - neuroinflammation , tauopathy , microglia , tau protein , inflammation , medicine , biology , immunology , neurodegeneration , pathology , alzheimer's disease , disease
Testosterone deprivation aggravated cognitive dysfunction in obese-insulin resistant rats. Testosterone deprivation aggravated cognitive decline as indicated by increasing time to teach plattorm (A) and decreasing time in target quadrant (B). High fat consumption and testosterone deprivation increased hippocampal ROS production (C) and increased hippocampal apoptosis as indicated by increasing number cortical TUNEL positive cells (D). Testosterone deprivation exacerbated glia morphological changed as indicated by increasing microglial volume (E) and astrocyte volume (F). NDS; ND-fed rats with sham operation, NDO; ND-fed rats with orchiectomy, HFS; HFD-fed rats with sham operation, HFO; HFD-fed rats with orchiectomy (N1⁄46 of each group). *p<0.05 in comparison with NDS, yp<0.05 in comparison with HFS, zp<0.05 in comparison with NDO.