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P2‐192: PCSK9 INHIBITOR ATTENUATES BRAIN MACROPHAGE INFILTRATION AND REDUCES AMYLOID BETA LEVELS IN RATS WITH CARDIAC ISCHEMIA/REPERFUSION INJURY
Author(s) -
Apaijai Nattayaporn,
Moisescu Dalila Monica,
McSweeney Christian,
Palee Siripong,
Maneechote Chayadom,
Jaiwongkam Thidarat,
Kerdphoo Sasiwan,
Chattipakorn Nipon,
Chattipakorn Siriporn C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.879
Subject(s) - medicine , microglia , ischemia , proprotein convertase , reperfusion injury , inflammation , endocrinology , lipoprotein , ldl receptor , cholesterol
igure 1. Effects of PCSK9 inhibitor on infiltrated macrophage, AD arkers, and brain mitochondrial function. (A) %infiltrate macrophage infilation. (B) Ab protein levels, (C) phosphorylated tau/tau, levels, (D) Brain itochondrial ROS levels, (E) Brain mitochondrial membrane potential hanges, (F) brain mitochondrial swelling. *p<0.05 vs. sham, yp<0.05 vs. ehicle. Jie Meng, Aiqin Zhu, Junjun Ni, Hiroshi Nakanishi, Zhou Wu, Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan; Qinghai Provincial Hospital, Xining, China; Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka, Japan. Contact e-mail: mjdejiejie@gmail.com
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