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P2‐161: TRANSCRIPTOME PROFILE OF NICOTINIC RECEPTOR–LINKED, BETA AMYLOID‐INDUCED NEUROTOXICITY
Author(s) -
Arora Komal,
Lantz Megan J.,
Belcaid Mahdi,
Nichols Robert A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.848
Subject(s) - biology , gene expression , transcriptome , microbiology and biotechnology , rna extraction , rna , gene knockdown , gene , transfection , neurotoxicity , chemistry , genetics , organic chemistry , toxicity
gliosis, and Ab plaque load. Basal glutamate (A) was measured prior to stimulus-evoked (B; 70 mM KCI, isotonic, pH 7.4) glutamate release (C). IHC analysis of CA1 VGLUT1 (E) and GFAP (F) density was determined as well as whole hippocampal Ap plaque pathology. All data represent mean 6 SEM and a two-way ANOVA with Holm-Sidak post hoc was used for statistical analyses. For (A-C) *p<0.05 C57BL/6J LFD (n1⁄41314) vs C57BL/6J HFD (n1⁄410-11), #p<0.05 AbPP/PS1 LFD (n1⁄411) vs AbPP/PS1 HFD (n1⁄411), xp<0.05 C57BL/6J LFD vs AbPP/PS1 LFD, zp<0.05 C57BL/6J HFD vs AbPP/PS1 HFD. For (D-F) *p<0.05 C57BL/ 6J LFD (n1⁄413) vs C57BL/6J HFD (n1⁄48); ##p<0.01, ###p<0.001 AbPP/ PS1 LFD (n1⁄47-10) vs AbPP/PS1 HFD (n1⁄411-12); xxp<0.01, xxxxp<0.0001 C57BL/6J LFD (n1⁄413-14) vs AbPP/PS1 LFD; zzzzp<0.0001 C57BL/6J HFD vs AbPP/PS1 HFD. Poster Presentations: Monday, July 23, 2018 P730