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P2‐157: BRAIN‐SPECIFIC REPRESSION OF AMPKα1 ALLEVIATES MEMORY DEFICITS AND SYNAPTIC FAILURE IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
Author(s) -
Zimmermann Helena R.,
Yang Wenzhong,
Zhou Xueyan,
Ma Tao
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.844
Subject(s) - ampk , synaptic plasticity , long term potentiation , protein kinase a , dendritic spine , neuroscience , hippocampal formation , microbiology and biotechnology , biology , chemistry , phosphorylation , biochemistry , receptor
fluency, trailmaking-task. Results: Linear regressions showed significant positive relationships between leptin and left(p1⁄40.006;standardized-B1⁄40.14) and right(p1⁄40.006;standardizedB1⁄40.14) hippocampus volume for the whole sample. Furthermore, lower age(p<0.001;standardized-B<-0.42), being female (p1⁄40.001;standardized-B1⁄40.08) and lower WHR(p1⁄40.01;standardized-B<-0.07) were predictive of higher left and right hippocampus volume in the same models. The interaction-terms were not significant. Leptin was not predictive for cognitive performance in this sample. In another independent sample(n1⁄453), left and right hippocampus volume derived from ultra-high-field anatomical MRI at 7T also showed significant correlations with leptin in older non-obese individuals after correcting for age, sex and percent body fat(both p<0.02). Conclusions: Results from this large crosssectional cohort indicated that leptin is positively associated with hippocampus volume in healthy individuals when accounting for negative effects of central obesity, which is in linewith previous findings(Witte2016). There was no significant association of leptin with cognitive measures, which is contrasting previous studies(Gunstad2008;Holden2009;Witte2016). The replication in an independent sample with 7T data underscores the validity of our findings. Future analyses of hippocampal subfields and leptin and additional mediation analyses will allow a more specific characterization of the association.