P2‐133: OMICS APPROACHES TO UNDERSTAND HEALTH DISPARITIES IN ALZHEIMER'S DISEASE

populations. However, there have been no comprehensive meta-analyses for APOE in Japanese populations so far. Methods:PubMed was initially surveyed to obtain literatures mentioning genotypic and allelic distributions ofAPOE in Japanese populations using three terms as follows: “APOE”AND “Japan*”AND “Alzheimer*”. Languages were not limited, that is, English as well as Japanese literatures were involved. Results: Four hundred and seventy-five literatures, published from December 1993 to December 2017, were obtained through the keyword search in PubMed. We are now carefully selecting literatures including APOE genotypic and/ or allelic frequencies. Other publicly available databases, The CochraneDatabase of Systematic Reviews and Ichushi (a bibliographic database in Japan), will be also surveyed to increase the number of literatures for themeta-analysis. After that, some statistical analyses, including a fixed-effectmodel analysis, will be applied to investigate and review risk andprotective effects ofAPOEgenotypes andalleles. Conclusions:The study is now on going. Thus, in the conference, we will present and discuss the first large-scale comprehensive metaanalysis for APOE with Japanese populations.