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P2‐090: SERUM ALBUMIN UNFOLDING IN RELATIONSHIP TO ALZHEIMER'S DISEASE
Author(s) -
Tsao Francis H.C.,
Amessoudji Amy,
Li Zhanhai,
Barnes Jill N.,
Meyer Keith C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.775
Subject(s) - albumin , medicine , serum albumin , endocrinology , alzheimer's disease , cognitive impairment , disease
showed an increased propensity to seizure-like dynamics and behavior as reported in human studies. Conclusions: The continued failure to translate basic research into clinical success strongly suggests that we are overdue for a rethinking how we research, understand and treat of AD and related dementias. The use of alternative computational methods allows for rapid investigation of the dynamics and motor system effects at the network level. These models thus help underscore the power of generative approaches to go beyond brute-force data mining and help researchers gain a deeper understanding of human-relevant network phenomena. These computational models also draw our attention to the urgent need to extend our focus beyond intrinsic cellular changes if we are to understand the dynamical consequences of network rearrangement in aging.