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P2‐087: EVALUATING NEUROIMMUNE IMAGING AS A BIOMARKER OF TISSUE CELLULARITY IN POSTMORTEM HUMAN BRAIN
Author(s) -
Chen Charles,
Gilligan Leah,
Wang Qing,
Franklin Erin E.,
Perrin Richard J.,
Cairns Nigel J.,
Morris John C.,
Wang Yong,
Benzinger Tammie L.S.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.772
Subject(s) - white matter , pathology , diffusion mri , medicine , connectome , nuclear medicine , magnetic resonance imaging , neuroscience , radiology , biology , functional connectivity
inflammatory/infiltrating immune responses. Conclusions: These unprecedented multiplexed images quantitatively recapitulate known hallmarks of brain aging (i.e. tauopathy) and provide an opportunity to understand the phenotypic landscape of cognitive decline and resilience. Given this, we believe MIBI will illuminate critical gaps in our knowledge, providing better understanding of disease mechanisms in AD, while highlighting future targets or cellular pathologies for therapeutic development. KV conducted the work for this abstract.