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P2‐083: THE INFLUENCE OF AGING AND TAU DEPOSITION ON MEMORY CONSOLIDATION USING A NOVEL ECOLOGICALLY VALID MEMORY TASK
Author(s) -
Leal Stephanie L.,
Jagust William J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.768
Subject(s) - episodic memory , forgetting , psychology , cognitive psychology , memory consolidation , semantic memory , explicit memory , task (project management) , hippocampus , cognition , neuroscience , management , economics
days. In first task, animals are presented with same juvenile during familiarization (T1) as was well as choice trials (T2) with a trial delay of 24 h. In second task, rats are presented with juvenile rat in T1 whereas in T2, a novel juvenile along with familiar juvenile (presented during T1) was also presented. Acute treatment with SUVN502 at 1, 3 and 10 mg/kg, p.o. was given for two days prior to T1 and T2. All trials lasted for 5 min and time spent by adult rats socially investigating juveniles was noted and compared. Ratio of investigation duration (ROI) and discriminative index (DI) was also calculated and compared among various groups. Results:With presentation of either same juvenile or novel juvenile, vehicle treated animals spent almost equal time with familiar juvenile in choice trial which indicates social memory deficit. SUVN-502 treated rats have spent significantly less time with familiar juvenile in choice trial which indicates that, SUVN-502 reversed the social recognition memory deficit in both tasks. Significant reduction in ROIwas noticed for groups treated with SUVN-502 at 1, 3 and 10 mg/kg, p.o., most effective being, 3 mg/kg, p.o. in either task.Conclusions:SUVN-502 could be promising intervention to alleviate social recognitionmemory deficits associated with dementia and Alzheimer’s disease.