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P2‐071: COMPARING CEREBRAL WHITE MATTER, CEREBELLAR, AND PONTINE REFERENCE REGIONS TO CHARACTERIZE FLORBETAPIR PET MEASUREMENTS OF AMYLOID‐β BURDEN IN PSEN1 E280A MUTATION CARRIERS AND NONCARRIERS FROM THE COLOMBIAN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE KINDRED
Author(s) -
Ghisays Valentina,
Protas Hillary,
Chen Yinghua,
DeMarco Eric L.,
Tariot Pierre N.,
Langbaum Jessica B.,
Quiroz Yakeel T.,
Lopera Francisco,
Reiman Eric M.,
Chen Kewei
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.756
Subject(s) - psen1 , white matter , presenilin , pathology , cerebellum , alzheimer's disease , neuroscience , psychology , medicine , biology , disease , magnetic resonance imaging , radiology
cortex and hippocampus was calculated using imageJ. Results: BCAS-operated mice showed no significant changes in the levels of APP, sAPPa and sAPPb at 5 weeks after the operation, and a significant increase of amyloid plaques in both cerebral cortex and hippocampus was detected 30 weeks after the operation. These data suggested that CCH with BCAS increases Ab deposits without altering Ab production. To assess the Ab clearance, we collected the brain interstitial fluid (ISF) with microdialysis to measure soluble Ab level in the brain ISF. Basal Ab40 and Ab42 levels of the brain ISF in the BCAS-operated mice were significantly decreased, whereas the Ab42 clearance rate was increased. These data suggested that CCH with BCAS inhibited the dynamics of ISF Ab, leading to the decreased level and increased clearance of ISF Ab, thereby facilitating the Ab aggregation. Conclusions:We showed that CCH accelerates Ab deposition in the brains of APP/ PS1mice by decreasing the level of Ab40 and Ab42, and increasing the Ab42 clearance. Our data suggested that CCH promotes soluble Ab aggregation resulting in enhanced Ab deposition.