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P2‐065: EFFECT OF NEUROGENIC COMPOUND NSI‐189 ON INDICES OF COGNITION AND ANXIETY IN A MOUSE MODEL (5XFAD) OF ALZHEIMER'S DISEASE
Author(s) -
Jolivalt Corinne G.,
Marquez Alexandra,
Quach David M.,
Johe Karl K.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.750
Subject(s) - barnes maze , neurogenesis , hippocampus , elevated plus maze , medicine , hippocampal formation , neurodegeneration , genetically modified mouse , memory improvement , rotarod performance test , behavioural despair test , psychology , anxiety , neuroscience , cognition , disease , antidepressant , transgene , spatial learning , psychiatry , chemistry , motor activity , biochemistry , gene
NSI-189 was shown to have significant antidepressant and pro-cognitive effects in patients with major depressive disorder in a Phase II clinical trial 6 weeks of treatment with NSI-189, significantly restored memory retention in the Barnes maze Learning abilities were significantly ameliorated by 12 weeks of oral administration of NSI-189. Thirteen weeks of treatment with NSI-189 improved short-term memory capacity of 7month old 5xFAD mice beyond the recognition capacity of control mice in the novel object recognition test. Using the repeated rotarod test showed that the motor performance as well as the learning ability of 5xFAD mice receiving daily NSI-189 treatment were significantly improved in 5xFAD. Anxiety had increased over the study period for untreated mice but daily treatment with NSI-189 partially reduced the developing anxiety for both control and AD mice.