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P2‐059: BDNF GENE DELIVERY INTO THE ENTORHINAL CORTEX IN RATS: SAFETY‐TOXICITY DATA
Author(s) -
Nagahara Alan H.,
Graham Lori,
Alisady Ali D.,
Staufenberg Eileen,
Elma Talia D.,
Kovacs Imre,
Tuszynski Mark H.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.744
Subject(s) - forelimb , entorhinal cortex , medicine , grip strength , neuroprotection , neuroscience , psychology , hippocampus , physical therapy
LY2886721 robustly blocked plaque accumulation with a dose targeting 70% soluble Ab lowering. However, when treatment began in old PDAPP mice, BACE1 inhibition was less effective in reducing Ab deposition. These results suggest that stage of pathology may be an important factor in the therapeutic application of BACE1 inhibitors and that a high dose regimen early in the Ab accumulation phase of ADmay be enough to completely block plaque accumulation.