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P2‐004: COGNITIVE REHABILITATION WITH TRANSCRANIAL DIRECT CURRENT STIMULATION: EFFECT ON COGNITION IN MAJOR OR MINOR NEUROCOGNITIVE DISORDERS —A RANDOMISED CONTROLLED PRELIMINARY STUDY
Author(s) -
Inagawa Takuma,
Yokoi Yuma,
Narita Zui,
Maruo Kazushi,
Okazaki Mitsutoshi,
Nakagome Kazuyuki
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.688
Subject(s) - transcranial direct current stimulation , neurocognitive , randomization , randomized controlled trial , cognition , medicine , physical therapy , dementia , clinical trial , brain stimulation , physical medicine and rehabilitation , psychology , stimulation , psychiatry , disease
subjects treated with AChEIs compared to the untreated group. We then stratified by APOE4 genotypes and found a trend for steeper cognitive changes in treated APOE4 carriers compared to treated non-carriers. In a sub-group of MCI treated subjects, we also found that cerebrospinal fluid AD biomarkers (i.e. amyloid-beta and p-tau) were significantly different at baseline compared to the non-treated MCIs. This indicates that the worsening in cognitive decline observed in the treatment group may not be only associated with the use of AChEIs but also due to the natural history of the disease progression. Conclusions: Our findings have an important implication for MCI management. Thus, it opens up the discussion of the off-label use of AChEIs in MCI and the evaluation of the risks versus the benefits of such treatment approach if there is no alternative to AChEIs.