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P1‐647: ARE DEPRESSIVE SYMPTOMS ASSOCIATED WITH AMYLOID STATUS IN SUBJECTIVE COGNITIVE IMPAIRMENT?
Author(s) -
Thayanandan Tony,
Alexopoulou Zoi,
Bailey Abigail,
Patel Neva,
Mikhail Ruth,
Wood Melanie,
Malhotra Paresh,
Perry Richard J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.659
Subject(s) - hamd , depression (economics) , medicine , cognition , psychology , cognitive impairment , audiology , clinical psychology , psychiatry , significant difference , economics , macroeconomics
scores were significantly higher in cognitively impaired patients, but only axial score discriminated between MCI and dementia. High vascular risk was related to impaired cognition, bradykinesia, axial, PIGD and FOG score, while whole brain WML volume was associated with PDD, freezing of gait and attention deficits. Furthermore, high vascular risk was identified as a potential predictor of both MCI and dementia in PD. Additionally, age and bradykinesia score were independently associated with PD-MCI and age, axial score and whole brain WML volume with PDD. Conclusions: cognitive disorders in PD are associated with more severe motor deficits and probably aggravated by elevated vascular risk, thus opening an avenue for possible preventive strategies in PD.