Premium
P1‐643: ANALYSIS OF RISK FACTORS FOR DEMENTIA BASED ON 10‐WORD MEMORY TEST RESULTS AND QUESTIONNAIRE RESPONSES IN HEALTHY JAPANESE INDIVIDUALS REGISTERED IN AN ONLINE REGISTRY
Author(s) -
Ogawa Masayo,
Sone Daichi,
Maruo Kazushi,
Shimada Hiroyuki,
Suzuki Keisuke,
Watanabe Hiroshi,
Matsuda Hiroshi,
Mizusawa Hidehiro
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.655
Subject(s) - mood , dementia , test (biology) , cognition , psychology , memory clinic , medicine , clinical trial , psychiatry , clinical psychology , disease , gerontology , cognitive impairment , paleontology , biology
diagnostic criteria. General linear models were used for statistical analysis of volumetric changes.We fitted model incorporating fixed sex, age, education, GDS, cognitive and APOE status. Results:140 non-demented subjects with memory complaints (92 SCD, 38 MCI), age 66.23(7.01), were analyzed. High SWB score correlated significantly p1⁄4.05 with lower atrophy rates of posterior parietal cortex (PPC) bilaterally, left medial-orbito-frontal, right superiorfrontal and superior-temporal thickness. Analyzing separately the transcendent and non-transcendent scores within this model – only transcendental domain score influenced the p1⁄4.05 negative correlation with atrophy rates of left PPC, right superior-frontal and left fusiform thickness. Conclusions:Level of SWB influenced atrophy rates in regions affected by AD pathology, associated with visual and spatial attention and with behavioral symptoms. The effect of the transcendental domain seems to be more pronounced.