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P1‐641: GENETIC RISK FOR ALZHEIMER'S AND BILINGUALISM: AN MEG STUDY
Author(s) -
Frutos Jaisalmer,
Toraño Federico Ramirez,
Fernández Ricardo Bruña,
Cuesta Pablo,
Rodríguez Rojo Inmaculada Concepción,
Sanz David Lopez,
Lopez Garcia Maria Eugenia,
Barabash Ana,
Dolado Alberto Marcos,
Delgado Losada Maria Luisa,
Higes Ramon Lopez,
Maestu Fernando
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.653
Subject(s) - neuroscience of multilingualism , apolipoprotein e , cognition , psychology , cognitive reserve , audiology , developmental psychology , cognitive impairment , neuroscience , medicine , disease
and over, fifty-four participants aged 60 to over under 70 were included in the study. Subjects with dementia or major mental disorders were excluded. We assessed cognitive functions using the Korean version of the Consortium to Establish a Registry for Alzheimer Disease neuropsychological battery (CERAD-NP), digit span forward (DS-F), digit span backward (DS-B) and the Frontal Assessment Battery (FAB) within 24 hours after quitting. The score of 1 or more standard deviation below appropriate norms of each test was classified as impairment. Results: All participants were male, and the mean age of each group was 45.962.0 years, 54.263.1 years and 64.662.8 years. There was no difference of the daily smoking amount (mean number 1⁄4 21.668.2) and urinary cotinine levels at the beginning of smoking cessation (mean 1⁄4 3491.2 6 2743.4 ng/ml) between the age groups. Impairment of the DS-B (18.2%) and constructional recall (18.2%) were the most frequent, followed by the impairment of word list recall (12.2%), constructional praxis (11.5%), and verbal fluency (10.7%). Among them, abnormalities of constructional recall, word list recall, and constructional praxis were different according to the age group and these impairments were more frequent as the age increased. Digit backward abnormality was seen in all age group without group differences. Conclusions:The effect of varenicline on the nicotine-withdrawal cognitive impairment may vary depending on subgroups, such as age. The future research is needed to understand the underlying mechanisms and improve the nicotine withdrawal-related cognitive deficits in treatment-seeking smokers of various age groups.