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P1‐597: AMYLOID NEUROIMAGING AND GENETICS INITIATIVE: IMPLEMENTING DNA COLLECTION USING NOVEL CONSENTING APPROACHES FOR AN IDEAS ADD‐ON STUDY
Author(s) -
Marshall Jeanine,
Faber Kelley,
Case Rose,
Lacey Kaci,
Hendrix James,
Rabinovici Gil D.,
Carrillo Maria C.,
Foroud Tatiana M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.609
Subject(s) - informed consent , comprehension , sample (material) , psychology , neuroimaging , family medicine , medicine , medical education , alternative medicine , psychiatry , pathology , computer science , chemistry , chromatography , programming language
27.7%. This phenomenon will generate an increase in diseases associated with aging, such as the frailty syndrome, considered as an extended process of progressive vulnerability to stress, that is associated with adverse events, such as hospitalizations, functional dependence and cognitive decline, which can eventually lead to death. Methods:An observational, longitudinal, retrospective, and comparative study was carried out, using the follow-up database of the ENASEM study (National Health and Aging Study in Mexico). Patients were grouped according to their degree of frailty on the Rockwood scale, and mortality was analyzed by means of survival analysis from 2001 until the date of death. We analyzed the change in the measurements of cognitive functioning, and the change in the basic and instrumental activities of daily life (ADLs) between 2001 and 2012. Results:Mortality: 4,082 people were analyzed, with 1,494 deaths and a follow-up of 40,661 years / follow-up / person. The patients were regrouped into 3 groups. Then the 10-year mortality analysis was made; robust 29%, pre-frail 34, frail 44%. Cognition: We analyzed 1,762 people who completed the 10-year follow-up and multivariate models were made by sex, schooling and frailty, calculating the likelihood ratio; pre-frail LR 1.10, p-value 0.68 (IC95% .698-1.73); frail LR 1.65, p value 0.104, (95% CI .900-3.05). Functional dependence: 4,082 people were analyzed and the change in the basic and instrumental ADLs carried out in 2001 and 2012 was analyzed. The prevalence of change in one or more ADLs was analyzed and adjusted by sex and age; pre-frail 2.4 LR, p <0.001, (IC95% 1.55 3.69), frail 3.3 LR, p<0.001 (IC95% 1.98 5.46). The prevalence of change in one or more instrumental ADLs was analyzed and adjusted by sex and age; pre-frail 1.04 LR, p 0.568, (IC95% 0.92-1.17), frail 0.85 LR, p 0.08 (IC95% 0.70 1.02. Conclusions: The Rockwood Clinical Frailty Scale is a useful tool to predict mortality and decline in basic functionality in older adult.