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P1‐536: IMMUNE ACTIVATION STATE IS ASSOCIATED WITH COGNITIVE SUB‐AGING WITHIN CLINICALLY NORMAL ADULTS
Author(s) -
Casaletto Kaitlin B.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.547
Subject(s) - medicine , cognition , neuropsychology , demographics , cognitive decline , immune system , gerontology , audiology , demography , disease , dementia , immunology , psychiatry , sociology
demographically adjusted, and z-scores were compared across groups using independent samples t-tests. Performance on semantic knowledge tests were also compared between groups. Verbal fluency z-scores were correlated with cortical thickness measurements extracted from a priori regions of interest (middle temporal gyrus, fusiform gyrus, inferior lateral and medial parietal regions). Results:PCA and lvPPA performed differently on letter fluency (t1⁄4 4.6, p1⁄40.0005), with PCA demonstrating average performance (z1⁄4 -0.2) and lvPPA demonstrating mildly impaired performance (z1⁄4-1.8). No group differences were observed on category fluency tasks (t1⁄40.49, p1⁄40.63), with both groups performing in the mildly impaired range. No semantic knowledge loss was observed in either group. Across all participants, category fluency was related to cortical thickness in left-hemisphere posterior cingulate cortex (r1⁄40.38, p1⁄40.03) and supramarginal gyrus (r1⁄40.36, p1⁄40.04). An association between letter fluency and left-hemisphere posterior cingulate cortex thickness was observed in PCA only (r1⁄40.43, p1⁄40.04). Conclusions:PCA and lvPPA demonstrate divergent performance profiles on verbal fluency tests related to posterior cortical neurodegeneration. This work has implications for improving early detection of atypical phenotypes of AD. Data collection is ongoing to understand how these populations perform in comparison to healthy older adults and amnestic MCI patients.