Premium
P1‐517: VALIDITY AND RELIABILITY OF THE 10/66 DEMENTIA RESEARCH GROUP COGNITIVE TEST BATTERY FOR EARLY IDENTIFICATION OF COGNITIVE DECLINE IN MEXICO
Author(s) -
Ortiz-Saavedra Berenice Dafne,
Austria-Corrales Fernando,
Astudillo-Garcia Claudia I.,
Acosta-Castillo Gilberto Isaac,
Sosa-Ortiz Ana Luisa
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.528
Subject(s) - dementia , verbal fluency test , psychology , cognition , cognitive decline , recall , neuropsychology , population , neuropsychological test , cognitive test , confirmatory factor analysis , clinical psychology , audiology , gerontology , developmental psychology , cognitive psychology , psychiatry , disease , medicine , statistics , structural equation modeling , mathematics , environmental health , pathology
to test the null hypothesis of no mean difference between delayed recall memory T-scores and language and executive function, respectively. Results: This pre-dialysis sample included 27 adults with a mean age of 66, a mean education of 13 years, and a mean estimated glomerular filtration rate (eGFR, in ml/min/1.73 m) of 13; the average length of time between the last study visit and participant report of dialysis initiation was 6 months. Delayed recall memory performance was the only measure, on average, which fell in the impaired range (T < 40) and demonstrated the lowest performance (T1⁄4 37.9) compared to both language (T 1⁄4 43.7; p 1⁄4 .03) and executive function (T 1⁄4 43.2; p 1⁄4 .05). Conclusions: Delayed recall memory performance may be preferentially reduced in advanced CKD patients prior to the initiation of HD. Future studies will investigate the pattern of pre-dialysis cognitive performance in a larger sample, further characterize the course of memory changes throughout HD, and determine whether impairment in this domain prior to HD suggests an irreversible neurodegenerative process that may not improve with HD treatment.