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P1‐516: CASE REPORT: FOREIGN ACCENT—A PRODOMAL STATE OF PRIMARY PROGRESSIVE APRAXIA OF SPEECH
Author(s) -
Giacominelli Carla,
Bertolucci Paulo Henrique Ferreira,
Pereira Fernando Vieira,
Barcelos Lorena Broseghini
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.527
Subject(s) - apraxia , syllable , audiology , psychology , fluency , stress (linguistics) , utterance , consonant , cued speech , speech recognition , vowel , aphasia , cognitive psychology , computer science , medicine , mathematics education
to test the null hypothesis of no mean difference between delayed recall memory T-scores and language and executive function, respectively. Results: This pre-dialysis sample included 27 adults with a mean age of 66, a mean education of 13 years, and a mean estimated glomerular filtration rate (eGFR, in ml/min/1.73 m) of 13; the average length of time between the last study visit and participant report of dialysis initiation was 6 months. Delayed recall memory performance was the only measure, on average, which fell in the impaired range (T < 40) and demonstrated the lowest performance (T1⁄4 37.9) compared to both language (T 1⁄4 43.7; p 1⁄4 .03) and executive function (T 1⁄4 43.2; p 1⁄4 .05). Conclusions: Delayed recall memory performance may be preferentially reduced in advanced CKD patients prior to the initiation of HD. Future studies will investigate the pattern of pre-dialysis cognitive performance in a larger sample, further characterize the course of memory changes throughout HD, and determine whether impairment in this domain prior to HD suggests an irreversible neurodegenerative process that may not improve with HD treatment.