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P1‐495: SLOW AND FAST DECLINE DEMENTIA: CLINICAL, PATHOLOGICAL AND GENETIC CHARACTERIZATION OF TWO RELATED CASES
Author(s) -
Poloni Tino Emanuele,
Davin Annalisa,
Medici Valentina,
Valente Maria Luisa,
Palmieri Ilaria,
Gagliardi Stella,
Chikhladze Maia,
Carlos Arenn Faye,
Vaccaro Roberta,
Abbondanza Simona,
Cereda Cristina,
Ceretti Arcangelo,
Guaita Antonio
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.505
Subject(s) - pathology , atrophy , cerebral amyloid angiopathy , parkinsonism , pathological , dementia , medicine , dementia with lewy bodies , disease , psychology
was used to evaluate relationships between regional NFT density and clinical characteristics. Results:Clinical and demographic information for this sample are depicted in table 1. The limbic NFT density accounts for just 21.2% of the variance in the cortical NFT density, correcting for age and sex. Limbic NFT density is significantly higher in female patients (p1⁄40.004), and higher burden is significantly associated with longer disease duration (p 1⁄4 0.010) and more severe memory symptoms (p1⁄40.008). Cortical, but not limbic, NFT density is inversely correlated with age of death (p<0.001). Cortical NFT density is significantly higher in females (p1⁄40.007) and in cases with an atypical clinical diagnosis (p1⁄40.013). A higher cortical burden is associated with more severe language symptoms (p1⁄40.015). Conclusions: The distinct clinical correlates of limbic and cortical NFT densities and the low variance of cortical NFT density accounted for by limbic NFT density suggests differential regional vulnerabilities to tau pathology.Understanding the pathological basis for clinical heterogeneity in AD presents an opportunity to hone mechanistic therapies for different clinical manifestations.