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P1‐494: REGIONAL NEUROFIBRILLARY TANGLE DISTRIBUTION AS A CONTRIBUTOR TO CLINICAL HETEROGENEITY IN ALZHEIMER'S DISEASE
Author(s) -
Petersen Cathrine,
Nolan Amber L.,
Paula França Resende Elisa,
Ehrenberg Alexander J.,
Miller Zachary A.,
Spina Salvatore,
Miller Bruce L.,
Seeley William W.,
Grinberg Lea Tenenholz
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.504
Subject(s) - neurofibrillary tangle , tangle , hippocampal sclerosis , alzheimer's disease , clinical dementia rating , limbic system , pathology , temporal lobe , psychology , dementia , hippocampus , neuroscience , hippocampal formation , senile plaques , disease , medicine , epilepsy , central nervous system , mathematics , pure mathematics
year) showed a slower rate of cognitive decline compared to the untreated HpSp (-7.1 points/year) and typical cases (-1.6), although not significant (p1⁄40.141 and p1⁄40.245, respectively). Limbic predominant did not show a difference (p1⁄40.901). Conclusions: The findings support the hypothesis that neuropathologic heterogeneity ofAD subtypes extends to the differential involvement of the cholinergic system. Although caution is needed due to the retrospective nature of our study, our findings suggest that cholinergic treatment may have a greater benefit in HpSp subtype of AD.