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P1‐477: A QUANTITATIVE SUSCEPTIBILITY MAPPING STUDY IN ALZHEIMER'S DISEASE
Author(s) -
Fan Xiang,
Qi Zhigang,
Yang Yanhui,
Li Hui,
Li Kuncheng
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.487
Subject(s) - quantitative susceptibility mapping , putamen , caudate nucleus , analysis of variance , magnetic resonance imaging , hippocampus , medicine , subiculum , pathology , nuclear medicine , psychology , radiology , dentate gyrus
normalization parameters. Next, the T1-w images were divided by the T2-w images. T1/T2 ratios were computed across the whole cortex and within 78 cortical AAL atlas regions. T1/T2 ratios were compared between groups using general linear models with Bonferroni correction. We further explored whether T1/T2 ratios were related to AD pathological hallmarks by comparing T1/T2 ratios of patients with abnormal/normal levels of cerebrospinal fluid (CSF) amyloid-ß1-42 (Aß42<680 pg/ml) and tau (>375 pg/ml).Results:ADsubjects showed a slight increased T1/T2 ratio across thewhole cortex (p1⁄4.05; Fig.1a). At the regional level 9 anatomical areas showed higher T1/T2 ratios in AD-related brain regions inAD subjects, including the inferior parietal lobule, angular gyrus, anterior cingulate gyrus, and precuneus (Fig.2, all p<.0006(1⁄4Bonferroni)). Analysis of CSFAb42 showed higher global T1/T2 ratio valueswith abnormalAb42 (p1⁄4.03) and abnormal total tau concentrations (p1⁄4.05) (Fig.1b&c). Conclusions:Contrary to our hypothesis, AD patients showed higher T1-w/T2-w ratios than controls. These increases tended to be most pronounced in anatomical areas known to be affected in AD, including the precuneus and parietal cortex. Increases in T1/T2 ratioswere associatedwith amyloid and tau pathology. In future research we will further study which precise biological processes are associated with T1-w/T2-w ratios in AD. Reference: 1. Glasser, M. F., &Van Essen, D. C. (2011). Mapping Human Cortical Areas In Vivo Based on Myelin Content as Revealed by T1and T2-Weighted MRI. Journal of Neuroscience, 31 (32), 1159711616.