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P1‐470: TAU‐PET TRACERS BIND TO MULTIPLE BINDING SITES ON THE TAU FIBRIL: INSIGHT FROM IN SILICO STUDIES
Author(s) -
Arul Murugan N.,
Nordberg Agneta K.,
Ågren Hans
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.480
Subject(s) - fibril , chemistry , biophysics , binding site , tau protein , amyloid fibril , crystallography , amyloid β , biochemistry , alzheimer's disease , biology , medicine , disease , pathology
binding in the hippocampus (p1⁄40.003), but not association cortex (p1⁄40.093) was reduced in AD (Table 2). Hippocampal reductions persisted after gray matter masking (p1⁄40.011) and partial volume correction (p1⁄40.050) (Table 3). Exploratory analyses revealed reductions in entorhinal cortex, and parahippocampal gyrus (Table 2, 3). Reduced hippocampal mGluR5 binding was associated with more severe disease (r 1⁄4 -0.534, p1⁄40.002) and lower episodic memory scores (r 1⁄4 0.398, p1⁄40.027) in the overall sample. Conclusions: [F]FPEB-PET revealed reductions in hippocampal mGluR5 binding in the early stages of AD. Further study is needed to refine the pattern of mGluR5 reductions and the associations with cognitive and functional impairment. Quantification of mGluR5 binding in AD may expand our understanding of AD pathogenesis as well as the development of novel treatments and biomarkers.