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P1‐469: PET IMAGING OF METABOTROPIC GLUTAMATE RECEPTOR 5 BINDING IN ALZHEIMER'S DISEASE
Author(s) -
Mecca Adam P.,
McDonald Julia W.,
Michalak Hannah R.,
Godek Tyler,
Harris Joanna,
Chen Ming-Kai,
Nabulsi Nabeel B.,
Salardini Arash,
Carson Richard E.,
Strittmatter Stephen M.,
Dyck Christopher H.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.479
Subject(s) - metabotropic glutamate receptor 5 , binding potential , metabotropic glutamate receptor , hippocampus , hippocampal formation , radioligand , neuroscience , medicine , glutamate receptor , alzheimer's disease , endocrinology , chemistry , psychology , receptor , disease
N 839 175 437 227 Demographics Age 73.86(7.16) 74.55 (5.91) 73.34 (7.10) 74.33 (8.05) .086 Sex (% male) 53.99 41.71 57.67 56.39 .001 Education (years) 16.00 (4) 16.00 (4) 16.00 (4) 16.00 (5) .051 Cognition MMSE 26.66 (2.82) 29.07 (1.10) 27.50 (1.83) 23.19 (2.03) <.001 ADAS-Cog 13 19.37 (10.17) 9.48 (4.26) 17.48 (6.83) 30.65 (8.32) <.001 ADNI-MEM -.00 (.89) .97 (.56) .08 (.65) -.91 (.55) <.001 ADNI-EF -.05 (.95) .60 (.70) .10 (.81) -.86 (.83) <.001 Neuroimaging ICV (dm) 1.51 (.16) 1.48 (.15) 1.52 (.16) 1.51 (.17) .034 W-score (whole-brain) .00 (.51) -.01 (.49) .01 (.52) -.02 (.50) .784 W-score (temporoparietal) .00 (.55) .01 (.51) .02 (.56) -.04 (.55) .426 Clinical Progression Follow-up (months) 24.00 (36) 36.00 (24) 36.00 (24) 12.00 (12) <.001 Conversion to MCI (n (%)) 37 (4.41) 37 (21.14) Conversion to AD (n (%)) 195 (23.24) 11 (6.29) 184 (42.11) -