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P1‐455: COMPARATIVE ANALYSIS OF DEFAULT‐MODE NETWORK (DMN) FUNCTIONAL CONNECTIVITY DISRUPTION AND MORPHOMETRIC CHANGES IN ALZHEIMER'S DISEASE PROGRESSION
Author(s) -
Grajski Kamil A.,
Bressler Steven L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.465
Subject(s) - neuroscience , default mode network , atrophy , dementia , psychology , neurodegeneration , posterior cortical atrophy , temporal lobe , resting state fmri , thalamus , functional connectivity , medicine , disease , pathology , epilepsy
(P<0.001, uncorrected for multiple comparisons). Results: Amyloid positivity was 81%, 47%, 39% and 18% for AD, MCI, CU APOE4 carrier and CU APOE4 non-carrier groups separately. In the overall, Alzheimer’s dementia and MCI analyses, mean cortical florbetapir SUVRs were associated with less gray matter bilaterally in posterior cingulate, precuneus, and temporal, parietal, frontal, and occipital regions, consistent with prior findings in persons with AD dementia and MCI. In the cognitive unimpaired APOE4 carrier analysis, mean cortical florbetapir SUVRs were associated with less gray matter bilaterally in medial frontal regions. Conclusions: Fibrillar Ab burden is associated with reduced gray matter in brain regions known to be preferentially affected by AD—and it is preferentially associated with reduced gray matter in frontal regions in cognitively unimpaired persons at risk for AD.