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P1‐444: A TWIN STUDY OF TYPE 2 DIABETES, BRAIN STRUCTURE, AND FUNCTION
Author(s) -
Karayiannis Christopher C.,
Moran Chris,
Beare Richard,
Sharman James,
Quinn Stephen,
Phan Thanh G.,
Wood Amanda,
Thrift Amanda G.,
Wang Wei,
Srikanth Velandai
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.453
Subject(s) - fractional anisotropy , hyperintensity , diffusion mri , type 2 diabetes , dementia , medicine , brain size , atrophy , white matter , psychology , neuropsychology , cardiology , diabetes mellitus , cognition , neuroscience , magnetic resonance imaging , endocrinology , disease , radiology
Background:The amyloid cascade hypothesis posits that amyloid proceeds and possibly initiates the spread of tau beyond the entorhinal/hippocampal complex. Study of individuals 78 years of age on average with normal cognition confirm strong associations between amyloid and tau burden within entorhinal and lateral temporal regions 6 8 years [range 32-71]) in the Framingham Heart Study (FHS). Methods: FHS subjects were members of the 3 generation cohort. 61% were male. PET was obtained using PiB and AV 1451 on a HRT+ PET machine. MPRAGE MRI was obtained from a Philips 3T Achieva machine. PET and MRI processing was performed similar to that of Lockhart et al. using SUVR with cerebellar gray matter reference region, but focused on cortical regions commonly affected by Alzheimer’s disease(AD) . Mixed Gaussian modeling was used to determine thresholds for PET global index positivity. Results:6 individuals were PiB positive and 2Tau positive, both of whichwere also PiB positive. Agewas significantly associated