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P1‐441: HYPERCAPNIA EXPOSES DEFICIENCIES IN CEREBROVASCULAR RESPONSE AND TISSUE OXYGENATION IN TRANSGENIC AD MICE
Author(s) -
Iordanova Bistra,
Klunk William E.,
Vazquez Alberto L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.450
Subject(s) - hypercapnia , cerebral blood flow , oxygenation , blood flow , medicine , room air distribution , anesthesia , cardiology , chemistry , respiratory system , physics , thermodynamics
phase pC-ASL, T1Wand C-PiB-PET data from 44 CN subjects (age 78.866.9), and 7 AD (77.366.7) were collected as part of the AIBL study. PET images evaluated through CapAIBL provided the standardized uptake value ratio (SUVR) of grey-matter to the cerebellum. Participants were classified as being Ab+ (vs Ab-) when above 1.4 SUVR leading to 30 CN Ab , 14 CN Ab+, and 7 ADAb+ subjects. The T1W data was processed to generate anatomical brain parcellation regions using an atlas-based approach (CurAIBL ). Regional CBF values were normalized using pre-central gyrus. Five main regions affected in AD pathology including frontal, parietal, lateral-temporal posteriorcingulate/precuneus (PCP) and hippocampus were considered. The analysis was conducted using a linear model to investigate the association of CBF with neocortical SUVR, controlling for age, gender, and APOE ε4 carrier status. Results were not corrected for multiple comparisons. Results: Figure 1 below shows the overall association between CBF and SUVR. While there were no significant differences in cognitive performance between CNAband CNAb+, in the CNAb+ group, a positive correlation between CBF and Ab burden was observed in the frontal (b1⁄43.761.6, p 1⁄4 0.05), parietal (b1⁄44.361.9, p 1⁄4 0.05), lateraltemporal (b1⁄45.161.7, p1⁄4 0.02), and hippocampus (b1⁄46.462.8, p 1⁄4 0.05), but not in PCP (b1⁄41.962.8, p 1⁄4 0.51). There was no significant associations in the CN Aband ADAb+ groups. Conclusions: This preliminary study shows a positive correlation of regional cerebral blood flow measured by ASL-MRI with Ab in the asymptomatic subjects, suggesting a potential compensatory mechanism against AD pathology.