Premium
P1‐435: WHITE MATTER HYPERINTENSITIES IN LATIN AMERICANS: FINDINGS FROM THE MARACAIBO AGING STUDY
Author(s) -
Diego Vincent P.,
Garcia-Hernandez Antonio,
Melgarejo Jesus D.,
Narkhede Atul,
Leendertz Reinier,
Pirela Rosa V.,
Terwilliger Joe,
Lee Joseph H.,
Blangero John,
Brickman Adam M.,
Maestre Gladys E.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.444
Subject(s) - hyperintensity , cardiology , dementia , medicine , heritability , pulse pressure , magnetic resonance imaging , blood pressure , psychology , disease , radiology , biology , genetics
East Asians and it was found to be stronger than Caucasians. . To address the underlying causal factors for these ethnicity-dependent difference, we screened the polymorphisms near APOE gene by assessing allele frequency and statistical analysis and found that some SNPs exhibit ε4/ε4-mediated risk for Alzheimer’s disease. Conclusions:In our study, we show that the e4/4 carriers were more vulnerable to AD in East Asian populations rather than Caucasians and Africans. Furthermore, the East Asians are highly prone to e4/4dependent atrophy in the cortical thickness and hippocampal volume compared to Caucasians. A polymorphism in the APOE promoter can modulate APOE e4-mediated risk for Alzheimer’s disease.