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P1‐426: CR1 POLYMORPHISM AND DEFAULT MODE NETWORK CONNECTIVITY IN MIDDLE AGE
Author(s) -
Blujus Jenna K.,
Korthauer Laura E.,
Driscoll Ira
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.435
Subject(s) - precuneus , default mode network , neuroscience , dementia , cognitive decline , psychology , disease , medicine , cognition
[APOE4], education (i.e. years of schooling) and their interaction on Ab burden (mean neocortical SUVR). Analyses were controlled for age, gender and, for ADAD, mutation type (APP/presenilin1/ presenilin2). Results: EYO was related to increased Ab burden in both cohorts (Figure1). In asymptomatic individuals with a PH of sAD, we found an effect of APOE4 status, education, and an APOE4*education interaction, such that the protective effect of education was stronger in APOE4 carriers (Figure 2). In presymptomatic ADAD, APOE4 had no effect on Ab accumulation, but completing higher levels of education were associated with lower Ab burden. Complementary analysis in ADAD highlighted an education*mutation type interaction, indicating a stronger effect of education in presenilin carriers (Figure 2). Conclusions:Our results suggest that a sporadic parental EYO might help to predict Ab accumulation in preclinical sAD. While APOE4 is highly associated with Ab burden in people at risk of sAD, APOE4 has no impact in ADAD. By contrast, environmental factors, approximated here using education, could affect biomarker progression in both variants of the disease, suggesting the existence of reserve mechanism both in individuals at risk of sAD and ADAD mutation carriers.