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P1‐420: ACCELERATED NEUROCHEMICAL CHANGES PRIOR TO PHENOCONVERSION TO FRONTOTEMPORAL LOBAR DEGENERATION IN PRESYMPTOMATIC MICROTUBULE‐ASSOCIATED PROTEIN TAU (MAPT) MUTATION CARRIERS: A LONGITUDINAL MRS STUDY
Author(s) -
Chen Qin,
Boeve Bradley F.,
Tosakulwong Nirubol,
Lesnick Timothy G.,
Brushaber Danielle,
Dheel Christina,
Fields Julie A.,
Forsberg Leah K.,
Gavrilova Ralitza H.,
Gearhart Debra,
Haley Dana,
Gunter Jeffrey L.,
Graff-Radford Jonathan,
Jones David T.,
Knopman David S.,
Graff-Radford Neill R.,
Kraft Ruth A.,
Lapid Maria I.,
Rademakers Rosa,
Syrjanen Jeremy,
Wszolek Zbigniew,
Rosen Howard J.,
Boxer Adam L.,
Kantarci Kejal
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.429
Subject(s) - asymptomatic , progressive supranuclear palsy , frontotemporal lobar degeneration , frontotemporal dementia , medicine , neurochemical , apathy , asymptomatic carrier , tau protein , dementia , pathology , gastroenterology , cardiology , oncology , psychology , alzheimer's disease , disease
Sandra Weintraub, Zbigniew Wszolek and LEFFTDS Consortium, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital, Charlestown, MA, USA; Massachusetts General Hospital, Boston, MA, USA; The Harvard Clinical and Translational Science Center, Boston, MA, USA; Brigham and Women’s Hospital, Boston, MA, USA; Massachusetts General Hospital/Harvard Medical School, Charlestown, MA, USA; Mayo Clinic, Rochester, MN, USA; University of California San Francisco, San Francisco, CA, USA; University of Pennsylvania, Philadelphia, PA, USA; University of California, Los Angeles School of Medicine, Los Angeles, CA, USA; The AFTD, Radnor, PA, USA; National Cell Repository for Alzheimer’s Disease (NCRAD), Indianapolis, IN, USA; Indiana University School of Medicine, Indianapolis, IN, USA; Washington University, St. Louis, MO, USA; Columbia University, New York, NY, USA; Mayo Clinic, Jacksonville, FL, USA; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; NIH, Bethesda, MD, USA; Univ of Penn, Philadelphia, PA, USA; Washington University, St. Louis, MO, USA; Memory and Aging Center, UCSF Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA; UCSF, San Francisco, CA, USA; National Alzheimer’s Coordinating Center, University of Washington, Seattle, WA, USA; University of British Columbia, Vancouver, BC, Canada; Gertrude H. Sergievsky Center at Columbia University, New York, NY, USA; The Bluefield Project, San Francisco, CA, USA; Penn FTD Center, University of Pennsylvania, Philadelphia, PA, USA; Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA; Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Northwestern University, Chicago, IL, USA. Contact e-mail: atouroutoglou@mgh.harvard.edu